Going only with what we have available and as our wingers are generally pretty shit, I'd go with a diamond in midfield with either Conor or DL chosen depending on the opposition!
Heaton
Guilbert - Engels - Mings - Targett
Nakamba
McGinn--------------Hourihane/luiz
Grealish
El Ghazi Wesley
Subs: Steer, Konsa, Hause, Hourihane/luiz,Lansbury,Kodjia, Davis.