We'll lose by 4 or 5 if Spurs are up for it.
Lineup I'd go:
Guzan
Hutton-Okore-Lescott-Cissokho
Lyden-Gueye-Westwood
Ayew-Gestede-Sinclair
Will still get destroyed but we gotta drop the ones who've been struggling the most recently (ie Richards, Agbonlahor, Veretout, Gil, Bacuna) and that means going back to likes of Sinclair, Gestede and giving Lyden a shot. Midfield options are very poor, ideally we'd be dropping Westwood too but without Sanchez the only options outside another untried kid like Calder is Richardson or pushing someone like Clark into DM and none of those options sound any better.