Science Thread

[Xann]

1 minute ago, wilko154 said:

This is literally the robot that ends the world

It'll need to move quickly if it's going to beat the suits to that end.

[villakram]

5 hours ago, Xann said:

It'll need to move quickly if it's going to beat the suits to that end.

The suitmakers are the real problem... 

[sne]

https://www.theguardian.com/science/live/2018/nov/26/mars-insight-lander-nasa-probe-live-updates

Quote

InSight has touched down on Mars!

A tense wait in the Nasa control room as the person in charge provides updates on InSight’s descent.

“Altitude 600m, 400m, 300m, 200m, 80m, 60m, 50m, 37m, 30m, 20m, 17m,” she says. A moment later: touchdown.

High fives, fist bumps and hugs in the control room.

Nasa said it could receive an image from InSight almost immediately, or there could be a few hours wait.

Good news for the scientists: InSight has already beamed back a photo. It’s taken through a dustcover, which will be removed, but shows what Nasa says is some debris on the surface of Mars.

InSight has landed on Mars

 

[chrisp65]

41 minutes ago, sne said:

InSight has landed on Mars

 

 

early reports, no atmosphere, but possible basic alien life

Spoiler

 

[chrisp65]

Alaska gets a 7.2 earthquake.

[sne]

1 hour ago, chrisp65 said:

Alaska gets a 7.2 earthquake.

Get ready for a Ice Road Truckers episode where something actually happens.

[A'Villan]

On 01/12/2018 at 10:04, chrisp65 said:

Alaska gets a 7.2 earthquake.

Sorry guys I'll try and put my barbell down more gently in future.

*runs away leaving coat behind*

[villakram]

Voyager 2 became the second man-made object to leave the solar system on Nov 5th 2018.

https://www.nasa.gov/press-release/nasa-s-voyager-2-probe-enters-interstellar-space

"For the second time in history, a human-made object has reached the space between the stars. NASA’s Voyager 2 probe now has exited the heliosphere – the protective bubble of particles and magnetic fields created by the Sun."

 

[villakram]

Loads of cool new results from the Deep Carbon Observatory, the lads in the pic below hang out at a depth of 1.3 km.

• "The genetic diversity of life below the surface is comparable to or exceeds that above the surface.

 

• The absolute limits of life on Earth in terms of temperature, pressure, and energy availability have yet to be found. The records continually get broken. A frontrunner for Earth's hottest organism in the natural world is Geogemma barossii, a single-celled organism thriving in hydrothermal vents on the seafloor. Its cells, tiny microscopic spheres, grow and replicate at 121 degrees Celsius (21 degrees hotter than the boiling point of water). Microbial life can survive up to 122°C, the record achieved in a lab culture (by comparison, the record-holding hottest place on Earth's surface, in an uninhabited Iranian desert, is about 71°C—the temperature of well-done steak).

 

• The record depth at which life has been found in the continental subsurface is approximately 5 km; the record in marine waters is 10.5 km from the ocean surface, a depth of extreme pressure; at 4000 meters depth, for example, the pressure is approximately 400 times greater than at sea level."

https://phys.org/news/2018-12-life-deep-earth-totals-billion.html

 

Edited December 11, 2018 by villakram

[Brumerican]

28 minutes ago, villakram said:

Voyager 2 became the second man-made object to leave the solar system .

 

I'm assuming the first object was a Blake Bortles 5 yds checkdown pass.

[villakram]

2 hours ago, Brumerican said:

I'm assuming the first object was a Blake Bortles 5 yds checkdown pass.

Kicking a man when he's down  Keep it up!

[Nigel]

Quote

We may finally know what causes Alzheimer’s – and how to stop it

 

21.5K

 

HEALTH 23 January 2019 , updated 30 January 2019

 

Alzheimer’s disease has destroyed neurons in the right-hand brain above

Jessica Wilson/Science Photo Library

By Debora MacKenzie

AFTER decades of disappointment, we may have a new lead on fighting Alzheimer’s disease. Compelling evidence that the condition is caused by a bacterium involved in gum disease could prove a game-changer in tackling one of medicine’s biggest mysteries, and lead to effective treatments or even a vaccine.

As populations have aged, dementia has skyrocketed to become the fifth biggest cause of death worldwide. Alzheimer’s constitutes some 70 per cent of these cases (see “What is Alzheimer’s disease”), yet we don’t know what causes it. The condition, which results in progressive loss of memory and cognitive function, usually over a decade or so, is devastating both to those who have it and to their loved ones.

The condition often involves the accumulation of two types of proteins – called amyloid and tau – in the brain. As these are among the earliest physical signs of the disease, the leading hypothesis since 1984 has been that the condition is caused by the defective control of these proteins, especially amyloid, which accumulates to form large, sticky plaques in the brain.

 

 

The bulk of research into understanding and treating Alzheimer’s has centred on this “amyloid hypothesis”. Huge sums of money have been invested in experiments involving mice genetically modified to produce amyloid, and in developing drugs that block or destroy amyloid proteins, or sometimes degraded tangles of tau.

It has become clear that this approach isn’t working. In 2018 alone, the US National Institutes of Health spent $1.9 billion on Alzheimer’s research. But according to a recent study, the failure rate of drug development for Alzheimer’s has been 99 per cent.

Some have begun to question the amyloid hypothesis. The lack of results has been compounded by the discovery that people – including some in their 90s with exceptional memories – can have brain plaques and tangles without having dementia. In a review of the research to date last year, Bryce Vissel at the University of Technology Sydney, Australia, concluded that there isn’t sufficient data to suggest that “amyloid has a central or unique role in Alzheimer’s”.

“The bacteria in the brain are not the result of Alzheimer’s, but they could be the cause”

In 2016, researchers discovered that amyloid seems to function as a sticky defence against bacteria. They found that the protein can act as an anti-microbial compound that kills bacteria, and when they injected bacteria into the brains of mice engineered to make Alzheimer’s proteins, plaques developed round bacterial cells overnight.

At the time, the team said it still believed that amyloid itself went on to cause the brain damage of Alzheimer’s, not bacteria. But a spate of subsequent studies have looked at microbes. Bacteria have been found in the brains of people who had Alzheimer’s when they were alive. But it hasn’t been clear whether the bacteria caused the disease or were simply able to enter brains damaged by Alzheimer’s.

Multiple teams have been researching Porphyromonas gingivalis, the main bacterium involved in gum disease, which is a known risk factor for Alzheimer’s. So far, teams have found that P. gingivalis invades and inflames brain regions affected by Alzheimer’s; that gum infections can worsen symptoms in mice genetically engineered to have Alzheimer’s; and that it can cause Alzheimer’s-like brain inflammation, neural damage and amyloid plaques in healthy mice.

A whole new hypothesis

“When science converges from multiple independent laboratories like this, it is very compelling,” says Casey Lynch of Cortexyme, a pharmaceutical firm in San Francisco.

Now researchers from Cortexyme and several universities have reported finding the two toxic enzymes that P. gingivalis uses to feed on human tissue in 99 and 96 per cent of 54 human Alzheimer’s brain samples taken from the hippocampus – a brain area important for memory (Science Advances, doi.org/gftvdt). These protein-degrading enzymes are called gingipains, and they were found in higher levels in brain tissue that also had more tau fragments and thus more cognitive decline.

The team also found genetic material from P. gingivalis in the cerebral cortex – a region involved in conceptual thinking – in all three Alzheimer’s brains they looked for it in.

“This is the first report showing P. gingivalis DNA in human brains, and the associated gingipains co-localising with plaques,” says Sim Singhrao at the University of Central Lancashire, UK, who wasn’t involved in the study. Her team has previously found that P. gingivalis actively invades the brains of mice with gum infections.

When Lynch and her colleagues looked at brain samples from people without Alzheimer’s, they saw that some had P. gingivalis and protein accumulations, but at low levels. We already know that amyloid and tau can accumulate in the brain for 10 or 20 years before Alzheimer’s symptoms begin. This, says the team, shows that P. gingivalis doesn’t get into the brain as a result of Alzheimer’s – but could be the cause.

 

The Porphyromonas gingivalis bacteria that can cause gum disease

A. Dowsett, Public Health England/Science Photo Library

When the team gave P. gingivalis gum disease to mice, it led to brain infection, amyloid production, tangles of tau protein and neural damage in the regions and nerves normally affected by Alzheimer’s. This suggests causation, says Lynch.

She adds that P. gingivalis fulfils an updated set of criteria for attributing a disease to a particular pathogen. These conditions are named Koch’s postulates, after Robert Koch, a founder of the germ theory of disease.

“The study does address most of Koch’s postulates,” says Robert Genco of the University at Buffalo, New York. “Future studies need to be in humans to be convincing.”

We don’t know how P. gingivalis gets into the brain, but there are plausible routes it could take. Your mouth normally hosts a diverse and relatively stable community of bacteria, but when dental plaque builds under the edge of your gums, it can form inflamed pockets in which P. gingivalis can thrive and release toxins.

This inflammation can lead to chronic periodontitis and tooth loss, and some studies have shown that people with fewer teeth are more likely to have dementia. The inflammation and toxins caused by P. gingivalis damage the lining of your mouth, which may make it possible for oral bacteria to enter the bloodstream and then other organs. Even if you don’t have gum disease, transient damage to your mouth lining from eating or tooth-brushing can let mouth bacteria into your blood, says Lynch.

The blood-brain barrier should protect your brain from microbes, but P. gingivalis can invade white blood cells and the cells lining blood vessels, so might cross it that way. It may also invade cranial nerves near the mouth, then spread from cell to cell towards the brain over a period of years.

“This is why years of efforts to treat Alzheimer’s have seen few results”

As to how P. gingivalis might cause dementia after it arrives in the brain, there are two clear possibilities. It may trigger the release of amyloid, the brain’s method of trying to contain the infection, and this may then kill neurons.

Or P. gingivalis may directly damage the brain. We already know that Alzheimer’s involves inflammation, an excessive immune response that ends up killing neurons instead of protecting them. P. gingivalis is known to cause inflammation in gum tissue, and it may do so in the brain as well.

In response to the new findings, David Reynolds of the Alzheimer’s UK charity said he is dubious that P. gingivaliscauses Alzheimer’s, because of the evidence showing that a person’s genes play a crucial role in the disease. “Strong genetic evidence indicates that factors other than bacterial infections are central to the development of Alzheimer’s, so these new findings need to be taken in the context of this existing research,” he said in a statement.

But a bacterial hypothesis for Alzheimer’s doesn’t conflict with genetic evidence. The human body’s propensity for inflammation can vary according to genetic variations that affect our immune systems, and this may influence how much damage P. gingivalis induces in a brain.

The biggest genetic risk factor for Alzheimer’s is a variant of the gene that makes the ApoE immune protein. Last year, a team in Sweden found that the gingipains released by P. gingivalis break up the ApoE protein into fragments, cleaving it at the site of a particular amino acid within the protein, and that these fragments may harm nerves. The ApoE4 variant of this protein contains more of this amino acid, suggesting that the reason people who make this variant are at a higher risk of developing Alzheimer’s may be because harmful levels of ApoE protein fragments build up more quickly in their brains than in those of other people.

Hope for treatments

The speed at which damage accumulates is a key factor in the disease. Although many people harbour P. gingivalis in their mouths, only some develop Alzheimer’s. Because it can be decades before Alzheimer’s symptoms appear, whether a person develops the condition could come down to how much damage occurs before they die of other causes.

“Alzheimer’s strikes people who accumulate gingipains and damage in the brain fast enough to develop symptoms during their lifetimes,” says Lynch. She says her team’s findings are a “universal hypothesis of pathogenesis”, fully explaining the causes of Alzheimer’s disease.

But Vissel warns that Alzheimer’s is a complex disease. “The answer is unlikely to be one-cause-fits-all. We need to keep open eyes.”

However, the new study is “very exciting”, he says. “Alzheimer’s is so common in people at advanced age that I think it can only be either some intrinsic property of the brain, or an infection.”

If this new hypothesis of Alzheimer’s is borne out, the good news is that it could lead to effective treatments for the condition. Although there is plenty you can do to reduce your risk of gum disease, Cortexyme is hoping it can stop or even reverse Alzheimer’s using molecules it has developed that block gingipains. The firm found that giving some of these to mice with P. gingivalis infections reduced brain infection, halted amyloid production, lowered brain inflammation and even rescued damaged neurons. “This provides hope of treating or preventing Alzheimer’s disease one day,” says Singhrao

Cortexyme reported last year that the best of its gingipain blockers had passed initial safety tests in people, and entered the brain. It also seemed to improve symptoms in participants with Alzheimer’s. The firm will launch a larger trial later this year.

The company also plans to test the drug against gum disease itself. Efforts to fight that have led a team in Melbourne to develop a vaccine for P. gingivalis that started tests in 2018. A vaccine for gum disease would be welcome – and if it also stops Alzheimer’s the impact could be enormous.

It is early days for this new hypothesis, and if the pursuit of amyloid-busting drugs over the past few decades has taught us anything, says Vissel, it is that a complex disease may not have a simple mechanism. Even if P. gingivalis is confirmed as a cause of Alzheimer’s, we don’t know yet whether it will turn out to be the only cause or one of several factors contributing to the disease.

“This paper is very important,” says George Perry at the University of Texas at San Antonio. “The view that pathogens might be one of several paths leading to Alzheimer’s disease fits my current thoughts of amyloid and tau being critical brain responses to injury, instead of the initiators.”

That, he says, is why years of efforts to treat Alzheimer’s by removing those proteins have seen few results: they are symptoms of the disease, not its cause. “This is a further turning point in the understanding that infections and inflammation can be at the heart of Alzheimer’s disease.”

Really glad this is getting the attention it deserves!

Horrible disease that took my dad.

Clicky

Edited March 5, 2019 by Nigel

[mjmooney]

There was a similar article in a recent issue of New Scientist. I'm certainly brushing and flossing a lot more diligently as a result. 

[Nigel]

25 minutes ago, mjmooney said:

There was a similar article in a recent issue of New Scientist. I'm certainly brushing and flossing a lot more diligently as a result. 

That was from New scientist, probably the same one!

I dont think that advice will have too many downsides!

[il_serpente]

10 hours ago, mjmooney said:

There was a similar article in a recent issue of New Scientist. I'm certainly brushing and flossing a lot more diligently as a result. 

Unfortunately, I fear i have left it too late.

[Xann]

Fossil of a 'missing link' in the Cetacean timeline found in Peru.

[tonyh29]

Saw the surgeon who regrew my knee cartridge today for a routine follow up ... he was telling me he’s been working on gene Therapy since he saw me where by the stem cell procedure I had will be obsolete in around 3 or 4 years once all the trails have been completed 

arthroscopy will be replaced by an injection and you’ll walk out the hospital 10 mins later ... still 18 months down time for the process to harden enough to be permanent but potentially must save millions 

also told me he’d just purchased a microsope for his knee unit for £1m ... which means you’ll no longer use MRI scans for trying to detect cartilage  damage , he can essentially look at the knee live and diagnose in minutes 

gotta love science 

[mjmooney]

12 minutes ago, tonyh29 said:

Saw the surgeon who regrew my knee cartridge today for a routine follow up ... he was telling me he’s been working on gene Therapy since he saw me where by the stem cell procedure I had will be obsolete in around 3 or 4 years once all the trails have been completed 

arthroscopy will be replaced by an injection and you’ll walk out the hospital 10 mins later ... still 18 months down time for the process to harden enough to be permanent but potentially must save millions 

also told me he’d just purchased a microsope for his knee unit for £1m ... which means you’ll no longer use MRI scans for trying to detect cartilage  damage , he can essentially look at the knee live and diagnose in minutes 

gotta love science 

Yeah, that is brilliant. I was talking to my eye surgeon about the catact op I had. He said when he first started doing them, years ago, they had to make six incisions in the eyeball, and put stitches in. With a high risk of infection, and a hit-and-miss success rate, it was pretty grim. Now? In and out in ten minutes, painless procedure, huge improvement in vision virtually immediately. It's amazing. 

[villakram]

A really, really interesting presser in store on Wednesday afternoon.

"On April 10th 2019, the Event Horizon Telescope (EHT) Collaboration will present its first results in multiple simultaneous press conferences around the world, and many satellite events organized by its stakeholder and affiliated institutions. Press conferences will be held simultaneously in Brussels (in English), Lyngby (in Danish), Santiago (in Spanish), Shanghai (in Mandarin), Tokyo (in Japanese), Taipei (in Mandarin), and Washington D.C. (in English), starting at 13:00 Universal Time."

https://eventhorizontelescope.org/blog/media-advisory-first-results-event-horizon-telescope-be-presented-april-10th

 

and some intro material

https://www.eso.org/public/usa/outreach/first-picture-of-a-black-hole/blog/

"The observations with the EHT and the GMVA were completed in April 2017... This lengthy time span between observations and results is normal in astronomy, as the reduction and analysis of the data is a careful, time-consuming process. Right now, all we can do is wait patiently for success to come — for a long-held dream of astronomers to be transformed into a reality."

Edited April 8, 2019 by villakram

[il_serpente]

8 hours ago, villakram said:

A really, really interesting presser in store on Wednesday afternoon.

"On April 10th 2019, the Event Horizon Telescope (EHT) Collaboration will present its first results in multiple simultaneous press conferences around the world, and many satellite events organized by its stakeholder and affiliated institutions. Press conferences will be held simultaneously in Brussels (in English), Lyngby (in Danish), Santiago (in Spanish), Shanghai (in Mandarin), Tokyo (in Japanese), Taipei (in Mandarin), and Washington D.C. (in English), starting at 13:00 Universal Time."

https://eventhorizontelescope.org/blog/media-advisory-first-results-event-horizon-telescope-be-presented-april-10th

 

and some intro material

https://www.eso.org/public/usa/outreach/first-picture-of-a-black-hole/blog/

"The observations with the EHT and the GMVA were completed in April 2017... This lengthy time span between observations and results is normal in astronomy, as the reduction and analysis of the data is a careful, time-consuming process. Right now, all we can do is wait patiently for success to come — for a long-held dream of astronomers to be transformed into a reality."

Let's hope they get their stories straight ahead of time.   Or will they be beyond each others' event horizons?