With the Man U game so close to this one, I wouldn't be taking chances on the fitness of Pau or Tielemans if they're not 100%.
We could go to a back 4 of Cash, Konsa, Carlos, Moreno. Or, Lenglet could come in as a direct swap for Pau.
Part of me is tempted to say we bring McGinn off the bench if we need him, as he's both one yellow away from being banned against Man U, and he's played a lot of football.
I'd potentially start with:
Luiz, Donk, Ramsey, Zaniolo, Diaby and Watkins ahead of a back 4, with McGinn, Youri, Pau, Bailey, Duran all ready to be brought on if things aren't going to plan.